Talk track

Key Messages

  • Evidence shows patients with a higher comorbidity are at greater risk of surgical bleeding, subsequent transfusion-related complications, and a higher incremental cost of bleeding.1*
  • VISTASEAL™ forms a rapid, adherent, and durable clot on targeted tissue, 2-4 and has demonstrated sustained hemostasis even in high-risk patients.2-6
  • VISTASEAL™ which consists of fibrinogen and forms a rapid, adherent, and durable clot on targeted tissue regardless of the patient’s coagulation profile,2-4,7
  • VISTASEAL™ has fewer setup steps and is faster to set up than the competition.†8
  • VISTASEAL™ has a pre-filled syringe and no need for additional warming, allowing you to quickly address the nuisance bleeding and move on with your procedure with the added confidence of reducing the risk of a re-bleed.10,11
  • The flexible tip may assist in reaching challenging anatomy within the thoracic cavity.

Detailed Talk Track

You mentioned patients undergoing thoracic surgery have characteristics and co-morbidities that put them at a higher risk for rebleeds and the negative consequences this can have on your practice, the patient and the hospital. Evidence shows a higher comorbidity burden was associated with a greater risk of surgical bleeding, greater risks of subsequent transfusion-related complications, and a higher incremental cost of bleeding.1* I noticed you chose to pack the surgical field rather than use a hemostat when there was continuous oozing. As I observed, it seemed to require you to go back and check the area multiple times, resulting in a disruption to your procedure. I’d like to introduce you to VISTASEAL™ which consists of fibrinogen and forms a rapid, adherent, and durable clot on targeted tissue regardless of the patient’s coagulation profile.2-4,7 With significantly fewer steps, VISTASEAL setup is faster than the competition†8 with pre-filled syringes and no need for additional warming, allowing you to quickly address the nuisance bleeding and move on with your procedure with the added confidence of reducing the risk of a re-bleed.10,11 The flexible tip may assist in reaching challenging anatomy within the thoracic cavity. Would you be happy to evaluate VISTASEAL™ in your next few high-risk patients to experience the results for yourself?

References

*In a retrospective study of 304,074 patients using the premier healthcare database. Comorbidities measured by Elixhauser Comorbidity index.
†Based on number of set-up steps and thawing time required for VISTASEAL™ Dual Applicator vs competitors.
1. Danker W. Increasing Incremental Burden of Surgical Bleeding Associated with Multiple Comorbidities as Measured by the Elixhauser Comorbidity Index: A Retrospective Database Analysis. Society for the Advancement of Patient Blood Management, September 16, 2022. Ethicon, Inc.
2. Bjelovic M, Ayguasonosa J, Kim RD, et al. A prospective, randomized, phase III study to evaluate the efficacy and safety of fibrin sealant Grifols as an adjunct to hemostasis as compared to cellulose sheets in hepatic surgery resections. J Gastrointest Surg. 2018. 22:1939–1949.
3. Nenezic D, Ayguasonosa J, Menyhei G, et al. A prospective, single-blind, randomized, phase III study to evaluate the safety and efficacy of Fibrin Sealant Grifols as an adjunct to hemostasis compared with manual compression in vascular surgery. J Vasc Surg. 2019: doi.org_10.1016_j.jvs.2018.12.051.
4. Lakshman S, Aqua K, Stefanovic A, et al. A prospective, single blind, randomized, phase III study to evaluate and efficacy of fibrin sealant Grifols as an adjunct to hemostasis during soft tissue open surgery. J Invest Surg. 2018;DOI:10.1080_08941939.2018.1489917.
5. Chetter I, Stansby G, Sarralde JA, et al. A prospective, randomized, multicenter clinical trial on the safety and efficacy of a ready-to-use fibrin sealant as an adjunct to hemostasis during vascular surgery. Ann Vasc Surg. 2017;45:127–137.
6. Hunt BJ. Bleeding and coagulapathies in critical care. 2014. N Engl J Med;370:847-859.
7. VISTASEAL™ Fibrin Sealant (Human). Full Prescribing Information. Instituto Grifols, S.A.
8. Thawing time and set-up steps comparison between VISTASEAL, EVICEL, and TISSEEL. Report 100708726-Rev 2. August 28, 2019. Ethicon, Inc.
9. VISTASEAL™ Fibrin Sealant (Human). Instructions for Use. Ethicon, Inc.
10. Shander A, Kaplan LJ, Harris MT, et al. Topical hemostatic therapy in surgery: bridging the knowledge and practice gap. J Am Coll Surg. 2014;219(3):570-579
11. Vyas K, Saha S. Comparison of hemostatic agents used in vascular surgery. Expert Opin Biol. Ther. 2013;13(12):1663-1672.

CONFIDENTIAL. FOR INTERNAL USE ONLY. NOT FOR USE WITH ANY CUSTOMER OR FOR EXTERNAL DISTRIBUTION.

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